Smoking Cessation Drugs: Nicotine Replacement Products
Type of Medication:
Medications and Their Commonly Used Brand Names
|Type of medication||Brand name|
|Nicotine patch/transdermal nicotine||
|Nicotine nasal spray||Nicotrol NS|
|Nicotine inhaler||Nicotrol Inhaler|
What They Are Prescribed For
How Nicotine Replacement Products Work
- Nicotine patch releases nicotine through your skin and into your bloodstream.
- Nicotine gum is chewed slowly, and then stored between the gum and cheek so that the nicotine can be absorbed through the lining of your mouth and into your bloodstream.
- Nicotine lozenges are allowed to dissolve slowly in your mouth to release nicotine at a slow rate.
- Nicotine nasal spray contains small doses of nicotine that are sprayed into your nasal passages and absorbed into your bloodstream.
- Nicotine inhaler contains nicotine that is inhaled through the mouth and is absorbed in the mouth and throat.
Precautions While Taking These Medicines
Do Not Smoke
See Your Doctor
Do Not Overuse These Products
- Nicotine patch—Do not use longer than 6-12 weeks.
- Nicotine gum—Do not chew or use more than 24 pieces a day; do not use longer than 12 weeks.
- Nicotine lozenges—Do not use more than 20 lozenges a day; do not use longer than 12 weeks.
- Nicotine nasal spray—Do not use longer than 12 weeks.
- Nicotine inhaler—Do not use longer than 12 weeks.
If You Are Pregnant or Breastfeeding, Talk to Your Doctor
Be Careful Around Children
Use With Adolescents and Older Adults
Manage Your Medications
Be Cautious With Certain Conditions
- Asthma or other breathing problems
- Common cold or a stuffy nose
- Dental problems
- Type 1 diabetes
- Heart or blood vessel disease
- High blood pressure
- Inflammation of mouth, throat, or esophagus
- Skin irritation or disorder
- Liver disease
- Nose polyps
- Overactive thyroid
- Sinus problems
- Stomach ulcer
- Recent stroke
- Temporomandibular joint disorder
Possible Side Effects
Symptoms of Nicotine Overdose
- Nausea and/or vomiting
- Increased watering of the mouth
- Abdominal pain
- Disturbed hearing and vision
- Difficulty breathing
Smoking Cessation Success
American Cancer Society http://www.cancer.org
Canadian Cancer Society http://www.cancer.ca
Health Canada http://www.hc-sc.gc.ca
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Guide to quit smoking. American Cancer Society website. Available at: http://www.cancer.org/healthy/stayawayfromtobacco/guidetoquittingsmoking/guide-to-quitting-smoking-types-of-nrt. Updated January 17, 2013. Accessed March 8, 2013.
Nicotine. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/. Updated January 18, 2013. Accessed March 8, 2013.
Nicotine lozenges. Colorado QuitLine website. Available at: https://colorado.quitlogix.org/preparing%5Fto%5Fquit/nrt/lozenge.aspx. Accessed March 8, 2013.
Nicotine replacement & other pharmaceutical therapies. Memorial Sloan-Kettering Cancer Center website. Available at: http://www.mskcc.org/mskcc/html/2553.cfm. Accessed March 8, 2013.
NRTs. Tobacco-Free website. Available at: http://www.tobaccofreeqc.org/quitting/nrts/. Accessed March 8, 2013.
Quit guide. Smokefree.gov website. Available at: http://www.smokefree.gov/qg-index.aspx . Accessed March 8, 2013.
Smokeless tobacco and cancer. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/factsheet/Tobacco/smokeless. Accessed March 8, 2013.
Using the nicotine patch and lozenge to help you stop smoking. University of Wisconsin Heart and Vascular Center website. Available at: https://www.healthdecision.org/assets/patient%5Fedu%5Fdocs/Nicotine%5FReplacement.pdf. Accessed March 8, 2013.
10/14/2008 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Shiffman S, Ferguson SG. Nicotine patch therapy prior to quitting smoking: a meta-analysis. Addiction. 2008;103:557-563.
12/16/2008 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Strandberg-Larsen K, Tinggaard M, Nybo Andersen AM, Olsen J, Gronbaek M. Use of nicotine replacement therapy during pregnancy and stillbirth: a cohort study. BJOG. 2008;115:1405-1410.
11/13/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: Piper ME, Smith SS, Schlam TR, et al. A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies. Arch Gen Psychiatry. 2009;66(11):1253-1262.
11/30/2010 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance: US Food and Drug Administration. Propoxyphene: withdrawal—risk of cardiac toxicity. US Food and Drug Administration website. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm234389.htm. Published November 19, 2010. Accessed November 30, 2010.
- Reviewer: Brian Randall, MD
- Review Date: 03/2013 -
- Update Date: 03/12/2013 -